Frequently Asked Questions

Here is a list of frequently asked questions which cover areas such as how suitable donors are found, the stem cell collection process and other elements of our work.

Find more information about blood cancer and donating blood stem cells.

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About becoming a donor

Who is eligible to become a potential blood stem cell donor?

Anyone between the ages of 18-55 and in general good health can become a potential blood stem cell donor. Pre-registration is possible from the age of 17. You must also be permanently living in the UK.

Please check that you are able to register by looking at this list. We have listed the exclusion criteria which is put together by experts and doctors at DKMS and are necessary to ensure the safety of both patients and donors.

What excludes someone from becoming a potential blood stem cell donor?

Weight under 7 stone 12lbs/50kg

The number of blood stem cells that can be collected during the donation process depends on the weight of the donor It is generally possible to collect more stem cells from people with a higher weight. If the amount of transplanted stem cells is low, the chances of a successful transplantation usually decreases. This is why there is a need for a minimum weight. If the donor has a low weight, the amount of blood stem cells collected during the donation process can be so low that it impacts the success of the transplantation. Therefore, registering as a potential blood stem cell donor and donating blood stem cells is not recommended if a person’s weight is below 7 stone 12lbs (50kg).

Obesity (e.g. body mass index (BMI)>40)

For registering as a potential blood stem cell donor, as well as for donating blood stem cells, there is a maximum Body-Mass-Index (BMI) limit of 40. While a blood stem cell donation is harmless for healthy people, there are health risks if the donor suffers from other pre-existing risky conditions. Severe obesity is unfortunately one of these risk factors. Severe obesity is problematic because it could lead to the two possible blood stem cell donation processes (peripheral blood stem cell donation and bone marrow collection) presenting a threat to the donor’s health. For bone marrow donation, a donor with obesity is at a higher risk of complications during anaesthesia. The harvest might also be impossible due to restricted access. Peripheral stem cell donation is not without unforeseeable risks, such as difficulty in correctly dosing the necessary medication, which also increases the side effects. The likelihood of complications increases with severe obesity. The maximum weight limit is not intended to discriminate against certain groups of people. It is in place to protect the health of our donors, which is our greatest responsibility.

Severe illnesses of the central nervous system or mental illness

The eligibility of a potential blood stem cell donor depends on the severity of the depression/anxiety. First of all, the question is whether or not the potential donor is limited due to their illness and how resilient they are in their everyday life. The donation process might be an additional mental burden, which has to be managed on top of everything else. It is not only the question of whether the donor will be able to reliably come to the donation appointment, but also how they can handle the situation after the donation. Even though they may be strangers, donors and recipients share a unique connection and many donors really worry about the recipient of their donation. There are also concerns related to many psychotropic drugs causing changes in the blood count. Neuroleptics are especially problematic, making it impossible to donate blood stem cells. If suffering from severe psychological illnesses, it is unfortunately not possible to register as a donor. Those illnesses include severe depression requiring treatment, borderline syndrome, any form of psychosis, schizo-effective disorders, and bipolar/manic affective illnesses. It is possible to register as a donor if suffering from a “mild” depression, receiving treatment for a limited amount of time, and feeling well enough to manage everyday life. This applies to donors whose medication contains less problematic substances, such as Citalopram or Fluoxetine.

Systematic autoimmune diseases or other severe chronic illnesses (e.g. diabetes or rheumatism)

It is not possible to register donors with diabetes mellitus type 1. The restriction is in place to protect the donor as well as the recipient. Diabetes mellitus type 1 is an autoimmune disease which leads to the destruction of the insulin-building cells of the pancreas. Since the transplanted cells are cells from the immune system, it is possible that the disease will be transmitted to the patient. Because the health of the patient is already very weak, it is impossible to say what effect the disease would have on them and severe complications are very likely to occur Additionally, due to the increased blood sugar level, diabetes can cause – to a varying degree - consequential damages of the nerves and blood vessels. We do not want to risk deterioration of the underlying disease through the stem cell donation. This is why we do not register people suffering from diabetes mellitus type 1. Diabetes mellitus type 2 causes the cells to become resistant to insulin. Consequently, glucose in the blood can not be absorbed by the cells. Increased blood sugar levels can damage the nerves and blood vessels. We do not want to risk of deterioration of the underlying disease through the stem cell donation. This is why someone suffering from diabetes is not eligible to register as a potential blood stem cell donor.

Rhuematism

It is not possible for someone to register as a blood stem cell donor if they are suffering from a rheumatic disease, even if they are not currently experiencing any symptoms. Rheumatic diseases include rheumatic arthritis, Bekhterev´s disease, and Juvenile Arthritis. The reason for excluding people suffering from those conditions is that they are autoimmune diseases. During the stem cell transplantation, cells of the immune system are transmitted into the recipient, leading to a risk of a possible negative reaction in the body of the recipient. Because the recipient is already physically burdened due to their disease, the chemotherapy in preparation for the transplantation, and the transplantation itself, a negative autoimmune reaction could potentially be fatal. This is why it is not possible to donate blood stem cells and therefore to register as a blood stem cell donor if suffering from autoimmune diseases.

Cancer (including being cancer-free, but having had cancer in the past)

Unfortunately, we cannot register people who have suffered from a malignant disease in the past. Anybody who has suffered from a malignant tumor (explicitly: suffered from a not clearly benign tumor), is not eligible to register as a blood stem cell donor. This does not depend on the success of the therapy or on how long ago the cancer occurred.

Addiction(alcohol, illicit or prescription drugs)

The occasional consumption of cannabis does not affect your eligibility to register as a blood stem cell donor. However, this only applies to occasional consumption. The reason for the restriction to occasional consumption only is that a donor’s reliability might be affected if any kinds of drugs are used regularly. While there may not be a direct health risk to the recipient, an unreliable donor might cause significant complications, because blood stem cell transplantations take place on a tight schedule to avoid putting the patient at risk. It is important for us to know which kind of drugs are consumed and for how long. If the drugs have been consumed for a long period of time, it might be better not to register as a blood stem cell donor. If that is not the case and if the potential donor is capable and willing to stop consuming, they can register as a potential blood stem cell donor.

Severe heart diseases

People suffering from well-regulated high blood pressure or a mitral valve prolapse can register as a potential blood stem cell donor, as long as there are no health problems stemming from the condition. The same is true for an exceptionally high or low resting heart beat, as long as it is steady. Most other heart diseases that require treatment or at least monitoring would unfortunately make you ineligible for registering as a potential blood stem cell donor, because they greatly increase the risk of complications during the donation. Those conditions include cardiac dysrhythmia, damage to the vascular walls, arteriosclerosis (especially if medication with anticoagulant drugs is necessary), heart attack, strokes, or structural defects of the heart such as valvular defects. If you have questions concerning any other condition that requires treatment, please get in touch via donor@dkms.org.uk.

Severe lung diseases

For someone with a chronic lung disease, including diseases in the early stages, there is a risk of further damage to their lung during a blood stem cell donation. Autoimmune diseases also carry the risk of transmitting the condition onto the recipient. Many lung diseases also increase the risk associated with general anaesthetic. Those suffering from a frequent or consistent dyspnoea are not eligible to register as a potential blood stem cell donor.

Severe kidney diseases

For people with chronic kidney diseases, including diseases in the early stages, there is a risk of further damage to their kidney during a blood stem cell donation. Autoimmune diseases also carry the risk of transmitting the condition onto the recipient.

Severe metabolic diseases

Those with severe metabolic diseases, including diseases in the early stages, might see their condition worsen or lapse during a blood stem cell donation. Especially problematic are metabolic diseases that have already caused consequential damages, e.g. damages to the vessels.

Severe tropical infectious diseases

Every pre-existing infectious disease can be transmitted onto the recipient during a blood stem cell donation. This is also the case if the donor does not have any symptoms because their immune system has been able to control the disease. However, the patient does not have a working immune system at the time of the transplantation so they are not protected from infectious diseases.

Infectious diseases like HIV, Hepatitis B or Hepatitis C, and Syphilis

Severe and life-threatening infectious diseases like HIV would make you ineligible to register as a potential blood stem cell donor. This is to protect the recipient, especially in cases were a complete healing from the disease is not verifiable (e.g. Hepatitis C).

Diseases of the haematopoietic system (blood disorders)

Diseases of the blood and the immune system are problematic, because the blood stem cells of the haematopoietic system and the immune system are transmitted through the stem cell transplantation. Conditions that have developed during the lifetime of the donor can also be transmitted during the transplantation, because the transplant includes mature cells of the immune system. Additionally, some diseases can increase the risk associated with the donation for the donor. For example, the donor would be at a higher risk of thrombosis or bleeding if they have a condition affecting the coagulation factors.


If you have any of the below conditions, we have good news, you are eligible to register as a potential blood stem cell donor:

Enlarged Thyroid/Underactive Thyroid (Hypothyroidism/Hashimoto’s Thyroiditis (stable and symptom-free; also when taking thyroid hormones or Iodide; does not apply to Grave’s disease)

If the underactive thyroid has been caused by an operation, it does not affect eligibility to donate blood stem cells, as long as the operation has not been because of Grave’s disease or a thyroid carcinoma. If the hypothyroidism is caused by an autoimmune disease of the thyroid (Hashimoto’s thyroiditis), the donor may only be approved for bone marrow donation (extracted from the pelvic bone, not the spine). This would be determined if and when the donor has been matched with a patient. If the underactive thyroid exists without any other pre-existing thyroid condition, it does not affect a potential donor’s eligibility to register.

High blood pressure (stable and well-controlled)

High blood pressure generally does not affect blood stem cell donation if the condition is well-regulated with drugs or through an adapted diet. High blood pressure would also not be a problem if it hasn’t caused any damage to the eyes, heart or vessels. If high blood pressure is well-regulated, it does not affect your eligibility to become a blood stem cell donor.

Hay fever, mild asthma (without attacks), food allergy

It is possible to register as a potential blood stem cell donor when suffering from an allergy (including food allergies, hay fever or drug allergies), with the exception of severe allergic reactions (e.g. allergic shocks or Quincke's Oedema) in the past. If you have suffered from severe allergic reactions in the past, please let us know via email: donor@dkms.org.uk, or tel: 020 8747 5620, because it may affect your eligibility as a donor.

Unipolar depression (mild depression, no previous maniac episodes, without any limitations in daily life)

Eligibility to become a potential blood stem cell donor depends on the severity of the depression. The first consideration is whether the potential donor is limited due to their illness and how resilient they are in their everyday life. The donation process might be an additional mental burden that has to be managed on top of everything else. It is not only a question of whether the donor will be able to reliably come to the donation appointment, but also how they can handle the situation after the donation. Even though they may be strangers, donors and recipients share a unique connection and many donors worry about the recipient of their donation. There are also concerns about many psychotropic drugs, which can cause changes to the blood count. Neuroleptics are especially problematic in this regard, making it impossible to donate blood stem cells. If the prospective donor is suffering from severe psychological illnesses, it is unfortunately not possible for them to register. Those illnesses include severe depression requiring treatment, borderline syndrome, any form of psychosis, schizo-effective disorders, and bipolar/manic affective illnesses. It is possible to register as a donor if suffering from mild depression and if the prospective donor is receiving treatment for a limited amount of time, and feeling well enough to manage everyday life. This applies to blood stem cell donors whose medication contains less problematic substances, such as Citalopram or Fluoxetine.

Iron-deficiency anaemia (treatable with iron supplement)

For iron-deficiency anaemia, the determining factor is the haemoglobin level. If the level is frequently below 11.5 mg/dl for women and 13.5 mg/dl for men, this does cause problems for donors and registration is not permitted. However, if the iron supplement is well-tolerated and the iron level, as well as the haemoglobin level, are in a normal range , you would still be eligible to register as a potential blood stem cell donor.

Basal cell carcinoma and cervical carcinoma in situ

Basal cell carcinoma and cervical carcinoma in situ do not affect your eligibility as a blood stem cell donor, if they have been removed completely and the control check-ups since have been without pathological findings. The reason for this is that in the cases of basal cell carcinoma and cervical carcinoma, it is not expected that the cancerous cells will spread (metastasizing).

Why is there an upper age limit of 55?

The upper age limit is in place in order to protect the safety of the donor and to provide the best possible treatment for patients. Younger people are more likely to be chosen as donors and are less likely to have health issues that could cause complications with donating. With age also comes an increase in risk from anaesthesia.

Can I register while breastfeeding?

You can register as a potential blood stem cell donor while breastfeeding, however you will need to be deactivated on the register until you have stopped. It is best to wait until after you have stopped breastfeeding before registering as a potential blood stem cell donor.

If you are pregnant or have recently given birth and are not breastfeeding, then you need to wait until six months after your baby is born before you can register.

When will my donor card arrive?

When you register to become a potential blood stem cell donor with us, we send you a do-it-yourself swab kit with instructions and a pre-paid envelope for returning your swabs to us. Once we have received your swabs back, we will send you an email to acknowledge this.

Your swabs will then be analysed at our lab and your tissue-type will be determined – this process usually takes between 3-6 weeks. Once your swabs have been analysed, you will go live on the UK stem cell registry. You will then receive your donor card to confirm this. Your donor card can take up to 12 weeks to arrive, this is because we send them out in batches every few months to save on postage costs.

Can I register for a specific person?

When you register as a potential blood stem cell donor, you are added to the UK stem cell registry and are on standby to save the life of anyone in need of a blood stem cell donation. Many people are inspired to register after seeing the story of a particular patient, but it is important to understand and be comfortable with that fact that you could be a match for anyone, and that you could be their best hope of survival. We ask that everyone that registers is prepared to donate to anyone who they are a match for.

Can I register if I live outside the UK?

You must live pernamently in the UK to register with DKMS UK, but you can register as a potential blood stem cell donor in other countries. In addition to the UK, DKMS also registers potential blood stem cell donors in the US (www.dkms.org), Germany (www.dkms.de) and Poland (www.dkms.pl). If you live outside of these countries, you can see if there is a registry in your country on the World Marrow Donor Association (WMDA) website: https://share.wmda.info/display/WMDAREG/Database

Online registration: how does that work with the swab kit?

You can register to become a potential donor on our website here. Simply fill in the online registration form and we’ll send you a DIY swab kit. All it takes to know if you’re someone’s match - is a quick swab inside your cheeks. You can register online for a DIY swab kit and take your cheek sample at home and then post us your swab sticks in the freepost envelope provided.

The kit contains two swabs, which should be gently rubbed on the inside of each cheek for 60 seconds on each side, and held to dry for a few minutes. These should then be placed in the swab envelope provided and sent back to our office in the pre-paid envelope. We will then send them to our laboratory, who will determine your tissue type, and your details will be placed anonymously onto the register of potential donors with your unique donor number.

Are there any risks associated with blood stem cell donation?

Peripheral Stem Cell Donation – (method used in over 90% of donations):

A peripheral blood stem cell donation is performed as an out-patient procedure and you will not be required to have a general anaesthetic. This technique has been applied in medicine since 1988 and has been performed by DKMS (Delete Blood Cancer UK) since 1996. According to our most recent research, no known long term effects have ever been recorded for either the procedure of donating or for the G-CSF injections that you would receive prior to the donation.

Bone Marrow Collection – (method used in less than 10% of cases):

A general anaesthetic is necessary for the bone marrow collection. The risk of life-threatening complications during any general anaesthetic is estimated by doctors at less than around 1:50,000. After the collection, local wound pain and in some cases nausea can occur as an after-effect of the general anaesthetic. Furthermore, a risk of infection exists to the same extent as it does for any wound. There are no known risks associated with this procedure for donating bone marrow.

How does DKMS finance itself and where does money raised by DKMS go?

DKMS is a charity and therefore relies on monetary donations to cover donor recruitment costs. The cost of the registration for one potential donor is £40. Our operations and administrative costs are paid out of a reimbursement fee we receive for further testing of donors (once they are identified as a potential match) and for the stem cell donation itself. We are committed to working efficiently and at the highest professional level and undertake an annual financial audit.

How will the security of my data be ensured?

DKMS only records, processes and makes use of your personal data in accordance with your informed consent. We adhere to legal guidelines on the use of any data and only keep what is legally permissible and necessary in order to find a suitable stem cell donor.

The protection and security of your data is of paramount importance to us. We are registered and adhere to the Data Protection Act 1998 and ensure that all employees are fully up to date and trained in this Act. Your personal data will be stored in our secure DKMS database and only your anonymised data will be transmitted to registries to find out if you are a potential match for a patient (data such as HLA tissue characteristics, age and gender and donor number).

Why does registering cost money?

DKMS is a charity and therefore relies on monetary donations to cover donor recruitment costs. The cost of the registration for one potential donor is £40.

Tissue typing is the determination of your tissue characteristics from your swab through analysis by a laboratory. We have to fund all registration costs entirely through voluntary monetary donations. This is why we are grateful to those who are able to support us by making a monetary donation to cover the cost of their own registration, and also for those who contribute towards this cost.

Will I permanently lose my stem cells?

If you choose to donate some of your blood stem cells, you won't actually lose them. Your blood stem cells completely replenish themselves within 2-3 weeks. This has to be the best natural cure to this devastating disease, and it resides within every one of us!

I am homosexual, am I allowed to donate my stem cells?

Yes. We register anyone who is in good general health and aged between 17-55 years of age.

Can you donate stem cells several times?

Occasionally, donors donate stem cells more than once to the same patient. Very occasionally, a donor will be asked to donate more than once to different patients, although this very seldom happens. In all cases, once you have donated, you will be set to inactive on the database for a period of at least 2 years.

Why isn’t stem cell collection possible in all major clinics?

Collecting blood stem cells is a highly skilled procedure and unfortunately not all clinics have the technological capabilities and expertise needed to do this.

I am already registered. Can I still register with DKMS too?

If you are already listed with the British Bone Marrow Registry (BBMR), the Welsh Bone Marrow Donor Registry (WBMDR), or with Anthony Nolan, you should not re-register. We and each of these organisations register donors to one single UK registry.

Can potential donors cancel their confirmed and committed blood stem cell donation?

If you change your mind about being a potential donor, you are able to withdraw your consent at any time by contacting the DKMS team. However, if you have been contacted to be a match, you should be aware that withdrawing could have an impact on the patient’s health. In the preparation stage, a patient will receive treatment which prepares them for your stem cell donation. If a withdrawal occurs at this late stage, the patient may not be able to survive without the subsequent donation of your stem cells.

Finding matching donors

How is blood stem cell donation different to blood donation?

Donating blood stem cells is similar to giving blood in 90% of cases. However, whether a donor and a patient in need of a blood stem cell transplant are a suitable match is decided on the basis of their human leukocyte antigen (HLA) type (tissue type), rather than on the basis of their blood type.

When you register as a potential blood stem cell donor, you complete a cheek swab which is then analysed at our lab to establish your tissue type. If your tissue type matches that of someone in need, we will be in contact as soon as possible – you could end up saving someone’s life!

There are two methods of donating blood stem cells.

What are HLA characteristics?

As a potential stem cell donor, your tissue type will be matched using human leukocyte antigen (HLA) typing. HLA are proteins or markers found on all cells in your body. These proteins are used by your immune system to recognise which cells belong in your body and which cells do not. If these proteins do not match, the patient’s body would reject the given stem cells of the donor. A close match means that the patient’s immune system would recognise your blood system as its own. With more than 16,000 known characteristics that can occur in millions of combinations, finding a match is extremely rare.

Approximately two thirds of patients who need a transplant do not have a suitable donor within their family and rely on the register to find an unrelated donor. In these cases, the patient’s doctor will search for an unrelated donor. To be considered a match, the patient and donor must have at least 8 out of 10 tissue characteristics in common, but ideally should have 10. The rarity of having matching HLA tissue-type characteristics is the reason finding matching donors is so difficult.

What happens if no matching donor can be found?

If no matching donor is found for a patient, their consultant will try to help the patient through other forms of treatment. Typical treatments are (but are not limited to) chemotherapy and radiation therapy, although this will vary depending on the patient’s specific needs. For many patients however, a blood stem cell donation may be their only hope of survival.

What if I'm a match for someone

How will I know if I'm a match for someone?

If you are found to be a match for someone in need, we will be in touch as soon as possible, either by phone, text message, email, or letter. We will try to reach you by phone as the first point of contact. It is important that we have up to date contact information for you in case you are identified as a matching donor. You can inform us of any changes to your details using our form.

When will the collection take place?

It is hard to say exactly when your donation will take place because it strongly depends on the patient’s condition. In most cases you would be asked to donate 1-3 months after the confirmatory blood test. We will always give you 3-4 weeks advance notice. If there are any important dates when you know you cannot donate, we will always try to accommodate your schedule if you let us know in advance.

Will I be compensated for the time I take off from work?

If you are not covered by your employer, DKMS has a financial assistance programme that deals with lost wage compensation. If you are found to be a match and qualify for assistance, your co-ordinator will provide more information on this.

Where will my stem cells be collected?

Your stem cell collection will be scheduled at a hospital depending on where you live, and we will cover all of your travel expenses.

Am I allowed to get to know the patient?

Yes, you are eventually permitted to meet the patient (with the patient’s consent), although you may need a little patience. The UK law states that there should be a two year window of anonymity from the date of the transplant, with contact being permitted only after this time and only with the patient’s full consent. Contact can be established before this time via the team at DKMS in the form of anonymised letters. We do our upmost to help facilitate this process and understand its value to both the patient and donor.

This may differ for stem cell collections for patients from abroad as each country has its own regulations.

Who covers the expenses?

There will be no cost to you. When a donor is matched with a patient, DKMS will cover the costs (including any travel, meals, or accommodation expenses that may be necessary). DKMS will also cover the costs for a companion to travel with you to the hospital. A donor’s own health insurance will never be used.

Whilst it is extremely rare to require follow up care, if it is ever needed, the donor’s costs will also be covered by DKMS. Other than that we are not legally allowed to make any payments or rewards for the provision of tissues, including bone marrow or blood stem cells for transplantation.

Can I choose the method of my donation?

There are two possible ways you may be asked to donate and the method of your donation is determined by what the doctors believe will be best for the patient. We ask our donors to be comfortable with both methods of donation. If you are not willing to donate through either method, you should notify your DKMS Co-ordinator, so they can let the patient’s doctor know that you are only comfortable proceeding with one method of donation. The final decision on the method of donation will always be made by you as donation is voluntary.

How high is the probability of becoming a candidate for a blood stem cell donation?

For every donor there is only a 4-5% chance that they will match a patient within the next ten years, so it is a bit like winning the lottery. You will only become part of this figure if your tissue type is very closely matched to a specific patient in need.

Will I be asked to donate again?

Sometimes the patient relapses e.g. because the immune system does not accept the new donor stem cells. If this happens we might get in contact with you again to consider a second donation, or a donor lymphocyte infusion, which for the donor is similar to the PBSC procedure, but without the stem cell stimulation process.

Medical queries

Why is there a minimum weight requirement?

To be able to register as a potential blood stem cell donor, you must weigh a minimum of 7st 13lbs, or 50kg. This minimum weight requirement is in place to ensure your body can produce enough extra stem cells and to ensure your safety as a donor. The amount of stem cells that can be collected from the donor is calculated using their weight. If the potential donor is under the weight restriction, then unfortunately they will not be able to provide enough extra blood stem cells for the blood cancer patient.

Can I register with asthma?

Whether or not you can register as a potential blood stem cell donor with asthma depends on how severe it is and how it is controlled. You can register if it is controlled with inhalers or non-steroidal oral medication, such as Monteleukast. However, if your asthma requires oral steroids or steroid sparing agents, then you are not able to register. You are also unable to register if your asthma has meant you have been admitted to hospital with the need for IV steroids or emergency care in the past two years. Additionally, if you have ever been admitted to intensive care as a result of an asthma attack, then you are not able to register.

I have epilepsy, can I register?

If you have Epilepsy, whether or not you can register as a potential blood stem cell donor depends on the frequency of your seizures.

It is possible to register as long as you have been seizure-free for the past 12 months without needing medication. However, if you are currently requiring medication or have recently had a seizure, then you are unable to register. You are also not able to register if seizures are related to a problem with, or injury to, the brain.

Can I register if I have Diabetes?

This depends on which type of Diabetes a person has.

If someone has type 1 Diabetes, then unfortunately they are unable to register as a potential blood stem cell donor. This is because tablets or insulin injections are needed and the donation process could put the donor at risk.

If a person has type 2 Diabetes, then they can possibly register. To be able to do so, their Diabetes has to be controlled by diet and there should be no other risk factors such as obesity, high blood pressure and cardiovascular disease.

You are also unable to register if you have Diabetes Insipidus. This is because the process of donation poses a risk to the person donating their blood stem cells.

How am I insured as a donor?

The statutory accident insurance protects all persons who take special action in the interest of another person or in the interest of the general public. The insurance protection exists by law without the requirement of a separate insurance and covers blood donors and donors of endogenous tissues. This statutory insurance protection therefore exists by law for you as a donor too. The stem cell collection process is insured, as well as also the trips to and from the collection clinic. Please contact us directly for further information.

Will an AIDS test be conducted during the tissue typing for the registration with DKMS?

At the point of registration, your mouth swab is examined and tested for the sole purpose of determining your tissue type. Therefore, no tests for specific infectious diseases are carried out at this time. If however, you are a match for a patient in need, we will need to ensure you have no infectious diseases that could be passed onto the patient. Therefore, it would be at this point that we would test your blood for diseases including HIV and chronic Hepatitis B and C.

What happens if I become/am pregnant?

You can register with us as a potential stem cell donor before, during or after your pregnancy. You will not however be eligible to donate during and for 6 months after your pregnancy, or during the time in which you are breastfeeding. We ask all females who have registered to inform us if they become pregnant so that we can temporarily deactivate them on our database for the duration of their pregnancy.

Will my existing medical condition prevent me from donating?

We take the health and safety of our donors very seriously. All donors are required to complete a health history questionnaire before proceeding. Any medical concerns are reviewed by a doctor to fully assess your ability to continue as a donor. Depending on your health status, it is possible that you may be deemed temporarily unavailable to donate, or need to be permanently removed from the registry.

About the collection process

Where do blood stem cell donations take place?

If you are ever identified as a matching donor for someone in need, you will go on to donate at one of our partnering hospitals. Collecting blood stem cells is a highly skilled procedure and not all hospitals have the technological capabilities and expertise needed to do this. The hospitals we use for donations have specialist staff and facilities, making them experts in the field.

If you are identified as the preferred match and proceed with the donation of your blood stem cells, DKMS will arrange for all the travel and accommodation costs of not just yourself, but also a friend or family member to support and keep you company during the donation. Our donation coordinators will also support you throughout your journey and are on-hand to answer any questions, queries or concerns you may have. They would also be happy to support you in discussing the process with your employers if you wish.

How do I donate blood stem cells?

There are two methods of donating blood stem cells. 90% of the time, the method of donation is peripheral blood stem cell collection. In this method, a thin sterile needle takes blood from one of the donor’s arms and a machine extracts the blood stem cells from it. The donor’s blood is then returned to them through their other arm. This is an outpatient procedure that is usually completed in 4-6 hours.

Bone marrow is used as the method of donation for the remaining 10% of the time. Bone marrow is not extracted from the spine, but from the pelvic bone using a special thin sterile needle.

What is G-CSF?

G-CSF (granulocyte-colony stimulating factor) is a naturally occurring growth hormone that stimulates the production of stem cells in the blood of the donor before collection. Donors donating via peripheral blood stem cell collection receive injections of G-CSF for four days prior to donation.

How will I be prepared for the blood stem cell collection?

Before the collection, you will be examined thoroughly by a doctor to ensure that you are in good general health. This comprehensive examination ensures that the stem cell collection will take place in as risk-free a way as possible, for you and for the patient.

Before the stem cell collection, you do not need to comply with any particular rules of conduct or limitations. However, you should avoid any and all risks that could lead to illnesses or serious injuries which would subsequently put the stem cell donation at risk.

How does the patient feel when she/he is back at home again?

The aim is that the patient can lead a normal life after he/she has been discharged from hospital and is back home. Initially however he/she must follow certain rules in order to reduce the risk of infection (including staying away from large crowds etc.). For some patients, side effects can occur for longer periods of time and these can include skin rashes, hair loss, and a low level of saliva and tear production.

What are the first signs of a blood stem cell transplantation’s success?

Two to four weeks after a transplant, an increase in the patient’s white blood cells would be the initial indicator that the new stem cells were fulfilling their task and forming healthy blood cells. With a continual increase in the white blood cells, the chances of a complete cure increase too.

Where is bone marrow taken from in the second method of collection? Is it near my spine?

No, the bone marrow is not taken from anywhere near the spine. It is extracted from the back of your hip bone. This alternative method of extraction is the least often used (10% of cases).

Can my blood stem cells transmit diseases that the patient did not have before?

If you are a match for a patient you would have numerous medical assessments before the donation and will be screened thoroughly to ensure you are a completely suitable candidate.

What complications can arise for a patient who has received a blood stem cell donation?

Complications during the preparatory phases generally occur in the form of the known side-effects of chemotherapy and radiation therapy, such as nausea and regurgitation. During the initial period after the donation, a higher risk of infection generally exists since the patient’s immune system is strongly weakened after the preparatory phases and it can only recover again gradually. Unfortunately, setbacks can also occur because, in rare circumstances, not all cancer cells were destroyed.

That means that a renewed outbreak of the Leukaemia can occur again even after the donation. It can also be that the new stem cells prove to be incompatible with the patient’s own body tissues and this subsequently leads to a reverse rejection reaction. This complication (Graft-versus-host Disease) can occur in various levels of severity. However, it can often be treated successfully. If the donor’s stem cells do not grow or if it leads to a relapse of the disease, the donor might be asked whether he/she is willing to provide another stem cell donation.

How high are the chances of survival after a stem cell donation?

For 40-80% of patients who have a donation, the treatment is successful. The survival time after a donation depends on many different factors including the age and health condition of the patient, the timing of the donation, the type of underlying disease and on the emergence of potential complications.

Can I choose the method of my stem cell donation?

There are two possible ways you may be asked to donate some of your blood stem cells. The method of your collection is determined by what the doctors believe will be best for the patient and your individual choice. The final decision on the method of collection will always be made by you, as stem cell donation is entirely voluntary.

Why do people need blood stem cell donations?

In many cases, a blood stem cell donation is needed as a treatment for myeloma, lymphoma, or a form of leukaemia, such as acute lymphoblastic leukaemia, acute myeloid leukaemia, or chronic lymphocytic leukaemia. They are also given to patients who suffer from diseases of the hematopoietic cell system. These diseases can include various forms of leukaemia and lymph node cancers, severe aplastic anaemia, serious congenital immunodeficiency, and other diverse diseases of the red blood cells.

Working / volunteering for DKMS

How can I volunteer at DKMS?

If you are interested in volunteering at our office in Chiswick, and can spare one or two days a week, we’d love to hear from you!

Just email us at volunteering@dkms.org.uk for more information.

About DKMS

What does DKMS do?

DKMS is a global organisation dedicated to the fight against blood cancer. DKMS operates in the UK, Germany, USA, Poland and Spain. Together we have built a worldwide organisation, supported by more than 6.3 million potential lifesavers. Our vision is to provide every blood cancer patient with a matching donor or help with access to treatment – around the globe. We want to see our vision to delete blood cancer become a reality by recruiting, retaining and motivating potential blood stem cell donors globally to saves patient's lives. We are a registered UK charity.