Some people donate blood stem cells more than once, either to the same patient or to a different one. If you have blood stem cells removed, your body will regenerate them in a couple of weeks. So it is possible to donate more than once.
To minimise the strain on donors as much as possible, we limit the number of times a donor can donate to twice for either peripheral blood stem cell collections or bone marrow collections.
In all cases, once you have donated, you will be set to inactive on the database for a period of at least two years.